First-in-human and multicenter phase I study of OSCA therapy for knee osteoarthritis

Dae Keun Suh ^1,10, Sang Hak Lee ^2,10, Yohan Bae ³, Hee-Jin Kang ³, Seunghee Lee ⁴, Mijin Kim ⁴, JongCheon Na ³, Ali Mobasheri ^5,6,7,8, Kyung-Sun Kang ^4,9, Kyoung Ho Yoon ¹

¹ Department of Orthopaedic Surgery, Kyung Hee University Hospital 23, Seoul, Republic of Korea
² Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea
³ Kangstem Biotech Co., Ltd, Hongwoo Building, Seoul, Republic of Korea
⁴ Stem Cell and Regenerative Bioengineering Institute, Global R&D Center, Kangstem Biotech Co. Ltd, Seoul, Republic of Korea
⁵ Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
⁶ Department of Personalized Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
⁷ Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
⁸ Faculté de Médecine, Université de Liège, Quartier Hôpital — Avenue Hippocrate 15 (Bât. B36), Liège, Belgium
⁹ Adult Stem Cell Research Center, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea

게재지 <Experimental & Molecular medicine>

Zonally patterned demineralized bone matrix–meniscus ECM composite scaffold directing region-specific fibrochondrogenic and angiogenic responses

Hee-Woong Yun ^1,2, Chae-Won Yun ^2,3, Mi Jeong Kim ^2,3, Yeeun Kim ^2,3, Gaeun Shim ^2,3, Sujin Noh ^2,4, Ho Jin Lee ², Sumin Lim ¹, Jun Young Chung ¹, Jae-Young Park ⁵, Do Young Park ^1,2,3

¹ Department of Orthopedic Surgery, School of Medicine, Ajou University, Suwon 16499, Republic of Korea
²Cell Therapy Center, Ajou University Medical Center, Suwon 16499, Republic of Korea
³Ajou University, Leading Convergence of Healthcare and Medicine, Institute of Science & Technology (ALCHeMIST), Suwon 16499, Republic of Korea
⁴Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea
⁵Department of Orthopaedic Surgery, CHA University, CHA Bundang Medical Center, Seongnam 13496, Republic of Korea

게재지 <Regenerative Biomaterials>

Treatment of osteoarthritic knee with high tibial osteotomy and allogeneic human umbilical cord blood–derived mesenchymal stem cells combined with hyaluronate hydrogel composite

Bo Seung Bae ¹, Jae Woong Jung ¹, Gyeong Ok Jo ¹, Seon Ae Kim ¹, Eun Jeong Go ¹, Mi-La Cho ², Asode Ananthram Shetty ³ and Seok Jung Kim ^1,4

¹ Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
² The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
³ Institute of Medical Sciences, Faculty of Health and Social Care, Canterbury Christ Church University, Canterbury, UK
⁴ Department of Orthopedic Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea

게재지 <Stem Cell Research & Therapy>

Anterior-to-Central Cartilage Defects of Arthritic Knee Showed Better Cartilage Regeneration Than Posterior Cartilage Defects Using Mesenchymal Stem Cell Implantation

Se-Han Jung ¹, Hong Seon Lee ², Min Jung ¹, Kwangho Chung ³, Sungjun Kim ², Jeehoon Choi ⁴, Chong Hyuk Choi ¹, Sung-Hwan Kim ⁵

¹ Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Orthopedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
² Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
³ Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Orthopedic Surgery, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea
⁴ Department of Orthopedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
⁵ Arthroscopy and Joint Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Orthopedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

게재지 <Arthroscopy: The Journal of Arthroscopic and Related Surgery>

Transplantable stem cell nanobridge scaffolds for accelerating articular cartilage regeneration

Sunho Park ^a,b,c, Ju Yong Na ^d, Yonghyun Gwon ^a,b,c, Woochan Kim ^a,b,c, Ju Yeon Kang ^d, Jong Keun Seon ^d, Jangho Kim ^a,b,c,e

^a Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea
^b Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea
^c Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju 61186, Republic of Korea
^d Department of Orthopedics, Chonnam National University Medical School & Hospital, Hwasun 58128, Republic of Korea
^e Institute of Nano-Stem Cells Therapeutics, NANOBIOSYSTEM Co., Ltd, Gwangju, Republic of Korea

게재지 <Biomaterials>

Fabrication of atelocollagen-coated bioabsorbable suture and the evaluation of its regenerative efficacy in Achilles tendon
healing using a rat experimental model

Yong Ho Yeo ^a, Seong Kyeong Jo ^b, Min Hee Kim ^c, Su Jeong Lee ^d, Seung Yun Han ^e, Mun Hyang Park ^f, Dae Young Kim ^f, Dae Yeung Kim ^b, In Ha Yoo ^g, Chan Kang ^h,
Jae Hwang Song ^b, Won Ho Park ^a

^a Department of Organic Materials Engineering, Chungnam National University, Daejeon, Republic of Korea
^b Department of Orthopedic Surgery, Konyang University Hospital, Daejeon, Republic of Korea
^c Department of Textile Engineering, Kyungpook National University, Republic of Korea
^d R&D planning team, Organoid Sciences Co., Ltd., 331, Pangyo-ro, Bundang-gu, Seongnam-si, Republic of Korea
^e Department of Anatomy, College of Medicine, Konyang University, Daejeon, Republic of Korea
^f Department of Pathology, College of Medicine, Konyang University, Daejeon, Republic of Korea
^g Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul

게재지 <International Journal of Biological Macromolecules>

Promoting angiogenesis and diabetic wound healing through delivery of protein transduction domain-BMP2 formulated
nanoparticles with hydrogel

Jae Wan Suh ¹ , Kyoung-Mi Lee ², Eun Ae Ko ², Dong Suk Yoon ³, Kwang Hwan Park ² , Hyun Sil Kim ⁴, Jong In Yook ⁴, Nam Hee Kim ⁴, Jin Woo Lee ^2,5

¹ Department of Orthopaedic Surgery, Dankook University College of Medicine, Cheonan, South Korea
² Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, South Korea
³ Department of Biomedical Science, Hwasung Medi-Science University, Hwaseong-Si, Gyeonggi-Do, South Korea
⁴ Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, South Korea
⁵ Brain Korea 21 PLUS Project for Medical

게재지 <Journal of Tissue Engineering>

Intra-articular Injection of Autologous Adipose-Derived Stem Cells or Stromal Vascular Fractions: Are They Effective for Patients
With Knee Osteoarthritis?
A Systematic Review With Meta-analysis of Randomized Controlled Trials

Kang-Il Kim ^1,2, Myung-Seo Kim ¹, Jun-Ho Kim ¹

¹ Department of Orthopaedic Surgery, Center for Joint Diseases, Kyung Hee University Hospital at Gangdong
² Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea

게재지 <The American Journal of Sports Medicine>

Three-dimensional printed polylactic acid scaffold integrated with BMP-2 laden hydrogel for precise bone regeneration

Misun Cha ^1,2, Yuan-Zhe Jin ^3,4,5, Jin Wook Park ¹, Kyung Mee Lee ², Shi Huan Han ³, Byung Sun Choi ², Jae Hyup Lee ^6,7,8

¹ Biotechnology Institute, Medifab Co. LTD., 70, Dusan-ro, Doksan-dong, Geumcheon-gu
² Department of Orthopedic Surgery, SMG-SNU Boramae Medical Center
³ Department of Orthopedic Surgery, College of Medicine, Seoul National University
⁴ Spine Department, The First Hospital of Jilin University, China
⁵ Jilin Engineering Research Center for Spine and Spinal Cord Injury China
⁶ Department of Orthopedic Surgery, SMG-SNU Boramae Medical Center
⁷ Department of Orthopedic Surgery, College of Medicine, Seoul National University
⁸ Institute of Medical and Biological Engineering, Seoul National University Medical Research Center

게재지 <Biomaterials Research>

Fabrication of decellularized meniscus extracellular matrix according to inner cartilaginous, middle transitional, and outer
fibrous zones result in zone-specific protein expression useful for precise replication of meniscus zones

Hee-Woong Yun ^a,b, Bo Ram Song ^b, Dong Il Shin ^b,c, Xiang Yun Yin ^a,b, Minh-Dung Truong ^b, Sujin Noh ^d, Young Jun Jin ^a,b, Hyeon Jae Kwon ^b,c, Byoung-Hyun Min ^a,b,c,
Do Young Park ^a,b

^a Department of Orthopedic Surgery, School of Medicine, Ajou University, Suwon, Republic of Korea
^b Cell Therapy Center, Ajou Medical Center, Suwon, Republic of Korea
^c Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea
^d Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea

게재지 <Materials Science & Engineering C>