First-in-human and multicenter phase I study of OSCA therapy for knee osteoarthritis

Dae Keun Suh ^1,10, Sang Hak Lee ^2,10, Yohan Bae ³, Hee-Jin Kang ³, Seunghee Lee ⁴, Mijin Kim ⁴, JongCheon Na ³, Ali Mobasheri ^5,6,7,8, Kyung-Sun Kang ^4,9, Kyoung Ho Yoon ¹

¹ Department of Orthopaedic Surgery, Kyung Hee University Hospital 23, Seoul, Republic of Korea
² Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea
³ Kangstem Biotech Co., Ltd, Hongwoo Building, Seoul, Republic of Korea
⁴ Stem Cell and Regenerative Bioengineering Institute, Global R&D Center, Kangstem Biotech Co. Ltd, Seoul, Republic of Korea
⁵ Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
⁶ Department of Personalized Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
⁷ Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
⁸ Faculté de Médecine, Université de Liège, Quartier Hôpital — Avenue Hippocrate 15 (Bât. B36), Liège, Belgium
⁹ Adult Stem Cell Research Center, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea

게재지 <Experimental & Molecular medicine>

Zonally patterned demineralized bone matrix–meniscus ECM composite scaffold directing region-specific fibrochondrogenic and angiogenic responses

Hee-Woong Yun ^1,2, Chae-Won Yun ^2,3, Mi Jeong Kim ^2,3, Yeeun Kim ^2,3, Gaeun Shim ^2,3, Sujin Noh ^2,4, Ho Jin Lee ², Sumin Lim ¹, Jun Young Chung ¹, Jae-Young Park ⁵, Do Young Park ^1,2,3

¹ Department of Orthopedic Surgery, School of Medicine, Ajou University, Suwon 16499, Republic of Korea
²Cell Therapy Center, Ajou University Medical Center, Suwon 16499, Republic of Korea
³Ajou University, Leading Convergence of Healthcare and Medicine, Institute of Science & Technology (ALCHeMIST), Suwon 16499, Republic of Korea
⁴Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea
⁵Department of Orthopaedic Surgery, CHA University, CHA Bundang Medical Center, Seongnam 13496, Republic of Korea

게재지 <Regenerative Biomaterials>